Develops asymmetric catalysts for photochemical reactions

An asymmetric catalyst that can be applied to photochemical reactions was successfully developed by a team led by Prof. Eric Meggs of the University of Marburg in Germany and Xiamen University in China. Related results were published in the 6th issue of Nature.

Many compounds will have two mirror images. The mutual relationship between them is like the left hand and the right hand and cannot be overlapped with each other by rotation. This property is called chirality. Two mutually mirrored chiral molecules form a pair of enantiomers. They are completely identical in their atomic composition, and many macroscopic physical properties and microscopic chemical reaction properties may also be exactly the same, but there may be great differences in the physiological activity in vivo. The most famous example is thalidomide (reaction stop) that was used as anti-pregnancy drug for pregnant women more than fifty years ago. The right-handed body of this medicine has a sedative effect, but its left-handed body has a strong teratogenic effect.

In order to chemically synthesize the desired absolute configuration of the chiral compounds, scientists are constantly studying the so-called asymmetric catalytic reactions, the core of which is asymmetric catalysts. The metal-containing asymmetric catalyst developed by the research team led by Prof. Meggs can now synthesize the absolute configuration of chiral compounds economically, efficiently, and selectively. What is particularly commendable is that the catalyst absorbs visible light and induces asymmetric chemical transformations. "Meeting says that visible light, such as sunlight, is the most important source of energy in green chemistry."

In an interview with a reporter from Science and Technology Daily, the first author of the paper, Dr. Huo Haohua, said: “For a long time, the application of photochemical reactions in synthetic chemistry has been subject to many restrictions. The biggest dilemma is the lack of effective strategies to control the three dimensions of organic molecules. Chiral structure: The few asymmetric photoreports reported so far are achieved through the combination of catalysts, and we have developed this multifunctional catalyst whose metal center is both the photosensitive center and the synthetic hand of light reaction. The only chiral source of the compound, which simultaneously plays the role of Lewis acid in chemical conversion, can achieve nearly perfect stereoselectivity and chemical selectivity with a single catalyst in the catalyzed alkylation of carbonyl compounds."

As a candidate for the “Thousand Talents Program”, the research team led by Professor Meggs is composed of researchers from the University of Marburg in Germany and Xiamen University in China. This research has also been awarded by the German Research Consortium and the China Scholarship Council. Funding. Speaking of the significance of the study, Professor Meggs introduced to the reporter of the Science and Technology Daily: "This year's Nobel Prize in Physics and Chemistry was awarded to scientists who have developed highly efficient light-emitting devices and researched ultra-high resolution fluorescence microscopes. The interaction between substances constitutes one of the most active fields in scientific research.Visible light-induced asymmetric reactions have also been a scientific challenge for synthetic chemistry. We have demonstrated a multifunctional catalyst in asymmetric visible-light catalytic reactions. Successfully applied, this result has provided inspiration for the design of new catalysts, which will provide a new way for efficient, green asymmetric synthesis.” (Reporter Li Shan)

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